Diego Simeone’s men come into the encounter in second place, two points ahead of their city rivals on the table.
For Real, this game comes on the back of a 1-1 draw with Barcelona in midweek and Santiago Solari will be keen to grab a win in the Derby.
Kick-off at the Wanda Metropolitano is by 4.15pm West African time.
Real Madrid starting XI: Courtois; Carvajal, Varane, Ramos, Reguilon; Modric, Casemiro, Kroos; Lucas, Vinicius, Benzema.
Atletico Madrid starting XI: Oblak; Arias, Giménez, Godín, Lucas; Lemar, Saúl, Thomas, Correa; Griezmann, Morata.
Saturday, February 9
16:15 Atletico Madrid vs Real Madrid