Tottenham left-back Danny Rose will miss Saturday's game because of a calf injury.
The Englishman sustained the problem after playing 90 minutes against Stoke, though his absence is not expected to be lengthy.
Manchester City midfielder Fernandinho begins a two-game ban after accumulating 10 yellow cards.
Top scorer Sergio Aguero will miss the game through injury, while defender John Stones is also unavailable.
Tottenham manager Mauricio Pochettino: "It is not about one result that we are going to show that we are ready or not ready [to challenge for the title].
"We have already shown we are ready to compete. We need to be consistent during the whole season and be the best team like Manchester City are doing today. We need to show ourselves that we can compete."
Manchester City boss: Pep Guardiola on their Champions League exit: "We did a better season than last season. We will be back and try to be stronger next season. This club is absolutely amazing."